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Caffeine can sometimes help, but too much can have the opposite effect

GLP-1 receptors are expressed in bone tissue, and preclinical studies have explored their role in bone metabolism

As noted by others ( Of note, the finding of a markedly greater benefit on HF of efpeglenatide amongst trial participants using SGLT2 inhibitors at enrolment in the AMPLITUDE-O CVOT highlights another important point (Lam et al., 2021)